Ongoing Clinical Trials of Human Immunodeficiency Virus Latency-Reversing and Immunomodulatory Agents
Identifieur interne : 001A16 ( Main/Exploration ); précédent : 001A15; suivant : 001A17Ongoing Clinical Trials of Human Immunodeficiency Virus Latency-Reversing and Immunomodulatory Agents
Auteurs : Héloïse M. Delagrèverie [France] ; Constance Delaugerre [France] ; Sharon R. Lewin [Australie] ; Steven G. Deeks ; Jonathan Z. Li [États-Unis]Source :
- Open Forum Infectious Diseases [ 2328-8957 ] ; 2016.
Abstract
In chronic human immunodeficiency virus (HIV)-1 infection, long-lived latently infected cells are the major barrier to virus eradication and functional cure. Several therapeutic strategies to perturb, eliminate, and/or control this reservoir are now being pursued in the clinic. These strategies include latency reversal agents (LRAs) designed to reactivate HIV-1 ribonucleic acid transcription and virus production and a variety of immune-modifying drugs designed to reverse latency, block homeostatic proliferation, and replenish the viral reservoir, eliminate virus-producing cells, and/or control HIV replication after cessation of antiretroviral therapy. This review provides a summary of ongoing clinical trials of HIV LRAs and immunomodulatory molecules, and it highlights challenges in the comparison and interpretation of the expected trial results.
Url:
DOI: 10.1093/ofid/ofw189
PubMed: 27757411
PubMed Central: 5066458
Affiliations:
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Delagrèverie</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>INSERM U941, Université Paris Diderot, Laboratoire de Virologie, Hôpital Saint Louis, Assistance Publique-Hôpitaux de Paris</institution>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Delaugerre, Constance" sort="Delaugerre, Constance" uniqKey="Delaugerre C" first="Constance" last="Delaugerre">Constance Delaugerre</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>INSERM U941, Université Paris Diderot, Laboratoire de Virologie, Hôpital Saint Louis, Assistance Publique-Hôpitaux de Paris</institution>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lewin, Sharon R" sort="Lewin, Sharon R" uniqKey="Lewin S" first="Sharon R." last="Lewin">Sharon R. 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Li</name><affiliation wicri:level="2"><nlm:aff id="af5"><institution>Brigham and Women's Hospital, Harvard Medical School</institution>,<addr-line>Boston, Massachusetts</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Boston</wicri:cityArea></affiliation></author></analytic><series><title level="j">Open Forum Infectious Diseases</title><idno type="eISSN">2328-8957</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In chronic human immunodeficiency virus (HIV)-1 infection, long-lived latently infected cells are the major barrier to virus eradication and functional cure. Several therapeutic strategies to perturb, eliminate, and/or control this reservoir are now being pursued in the clinic. These strategies include latency reversal agents (LRAs) designed to reactivate HIV-1 ribonucleic acid transcription and virus production and a variety of immune-modifying drugs designed to reverse latency, block homeostatic proliferation, and replenish the viral reservoir, eliminate virus-producing cells, and/or control HIV replication after cessation of antiretroviral therapy. 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Deeks</name></noCountry><country name="France"><noRegion><name sortKey="Delagreverie, Heloise M" sort="Delagreverie, Heloise M" uniqKey="Delagreverie H" first="Héloïse M." last="Delagrèverie">Héloïse M. Delagrèverie</name></noRegion><name sortKey="Delaugerre, Constance" sort="Delaugerre, Constance" uniqKey="Delaugerre C" first="Constance" last="Delaugerre">Constance Delaugerre</name></country><country name="Australie"><noRegion><name sortKey="Lewin, Sharon R" sort="Lewin, Sharon R" uniqKey="Lewin S" first="Sharon R." last="Lewin">Sharon R. Lewin</name></noRegion><name sortKey="Lewin, Sharon R" sort="Lewin, Sharon R" uniqKey="Lewin S" first="Sharon R." last="Lewin">Sharon R. Lewin</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Li, Jonathan Z" sort="Li, Jonathan Z" uniqKey="Li J" first="Jonathan Z." last="Li">Jonathan Z. Li</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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